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FLASH GENE
Symbol STRN4 contributors: mct - updated : 18-01-2011
HGNC name striatin, calmodulin binding protein 4
HGNC id 15721
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a putative caveolin -binding domain
  • a coiled-coil structure, playing an essential role in the targeting of STRN3 within spines, and also crucial for the homo- and hetero-oligomerization of these proteins
  • a Ca2+/calmodulin binding domain and eight (?seven) WD40 repeats in the C terminal region
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text membrane -bound
    basic FUNCTION
  • putative signaling and scaffolding protein
  • intracellular proteins, mainly expressed in neurones of the mammalian central nervous system where they are thought to be involved in vesicular traffic and Ca(2+) signalling
  • multimodular WD-repeat, calmodulin and calveolin-binding protein
  • PDCD10 and striatins exhibit opposing functions on the targeting of MST4 to the Golgi and Golgi positioning
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component STRIPAK contains the PPP2CA, the striatins (STRN, STRN3, STRN4), MOB4, FAM40A and FAM40B, the cerebral cavernous malformation 3 (CCM3) protein, and members of the germinal center kinase III family of Ste20 kinases
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • calmodulin, Ca2+ dependent, caveolin
  • STRN, STRN32, STRN4 binds directly to PPP2CA and PDCD10
  • MINK1 directly interacted with STRN4 (STRN4 reduced MINK1 activity in the presence of catalytic and structural subunits of PPP2CA)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS