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FLASH GENE
Symbol DNAJC2 contributors: mct - updated : 26-09-2012
HGNC name DnaJ (Hsp40) homolog, subfamily C, member 2
HGNC id 13192
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal zuotin-homology domain fused to a C-terminal two-repeat MYB domain
  • a J domain
  • a evolutionarily conserved zuotin domain
    • conjugated PhosphoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to Drosophila CG10565
    homolog to C.elegans dnj-11
    ortholog to yeast ribosome-associated J protein Zuo
    Homologene
    FAMILY
    CATEGORY chaperone/stress , regulatory , DNA associated , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus
    text
  • localized to the cytosol and associates with ribosomes
    • basic FUNCTION
  • acting as a cell cycle regulator
  • implicated in the regulation of cell growth
  • specifically recruited to histone H2A when it is ubiquitinated at Lys&
    • 8201;119 by means of a novel ubiquitin-interacting domain that is located in the evolutionarily conserved zuotin domain
  • at the onset of differentiation, specifically displaces polycomb-repressive complex 1 (PRC1) from chromatin and facilitates transcriptional activation
  • specifically binds to monoubiquitinated histone H2A and derepresses Polycomb target genes at the onset of cellular differentiation
  • recruited to typical Polycomb target genes, thereby putting it in a position to have an impact on differentiation and development
    • CELLULAR PROCESS cell cycle
    nucleotide, transcription, regulation
    protein, post translation, folding
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms a stable complex with HSPA14 (chaperones DNAJC2 and HSPA14 form the ribosome-associated complex)
    • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • reactive with antibodies anti MPM2
  • unfolded protein
  • heat shock protein
    • cell & other
    REGULATION
    Other phosphorylated in M phase
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    extensively overexpressed in leukemic cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    attractive target for leukemia T cell therapy
    ANIMAL & CELL MODELS