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FLASH GENE
Symbol ZPBP contributors: mct/npt - updated : 29-06-2022
HGNC name zona pellucida binding protein
HGNC id 15662
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
intraspecies paralog to ZPBP2
Homologene
FAMILY
  • zona pellucida-binding protein Sp38 family
    • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus
    text
  • localizes to the acrosome of spermatid (Lin 2007)
  • localization of ZPBP on the extracellular side of both the inner and outer acrosomal membrane during the cap phase of acrosomal development
    • basic FUNCTION
  • with ZPBP2, play cooperative roles during spermiogenesis (Lin 2007)
  • spermatid and spermatozoon protein having a role in sperm-egg interactions (Lin 2007)
  • most prominent protein of the inner acrosomal membrane extracellular coat (IAMC) of spermatozoa
  • role in acrosomal compaction
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGF66
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS