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FLASH GENE

Symbol

ZPBP

contributors: mct/npt - updated : 29-06-2022

HGNC name	zona pellucida binding protein
HGNC id	15662

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_007009 8 - 1195 NP_008940 - 351 - 2012 21911476 NM_001159878 8 - 1192 NP_001153350 - 350 - 2012 21911476

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

HOMOLOGY

intraspecies

paralog to ZPBP2

Homologene

FAMILY

zona pellucida-binding protein Sp38 family

CATEGORY

adhesion

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,nucleus
text	localizes to the acrosome of spermatid (Lin 2007)
	localization of ZPBP on the extracellular side of both the inner and outer acrosomal membrane during the cap phase of acrosomal development

basic FUNCTION	with ZPBP2, play cooperative roles during spermiogenesis (Lin 2007)
	spermatid and spermatozoon protein having a role in sperm-egg interactions (Lin 2007)
	most prominent protein of the inner acrosomal membrane extracellular coat (IAMC) of spermatozoa
	role in acrosomal compaction

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SPGF66

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS