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FLASH GENE
Symbol ZPBP contributors: mct/npt - updated : 29-06-2022
HGNC name zona pellucida binding protein
HGNC id 15662
DNA
TYPE functioning gene
STRUCTURE 252.59 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1195 - 351 - 2012 21911476
8 - 1192 - 350 - 2012 21911476
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
intraspecies paralog to ZPBP2
Homologene
FAMILY
  • zona pellucida-binding protein Sp38 family
    • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus
    text
  • localizes to the acrosome of spermatid (Lin 2007)
  • localization of ZPBP on the extracellular side of both the inner and outer acrosomal membrane during the cap phase of acrosomal development
    • basic FUNCTION
  • with ZPBP2, play cooperative roles during spermiogenesis (Lin 2007)
  • spermatid and spermatozoon protein having a role in sperm-egg interactions (Lin 2007)
  • most prominent protein of the inner acrosomal membrane extracellular coat (IAMC) of spermatozoa
  • role in acrosomal compaction
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGF66
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS