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FLASH GENE
Symbol ZPBP contributors: mct/npt - updated : 29-06-2022
HGNC name zona pellucida binding protein
HGNC id 15662
Corresponding disease
SPGF66 spermatogenic failure 66
Location 7p12.2      Physical location : 49.977.025 - 50.132.860
Synonym name
  • inner acrosomal membrane IAM38
    • Synonym symbol(s) SP38, ZPBP1, FLJ93221
    DNA
    TYPE functioning gene
    STRUCTURE 252.59 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1195 - 351 - 2012 21911476
    8 - 1192 - 350 - 2012 21911476
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    intraspecies paralog to ZPBP2
    Homologene
    FAMILY
  • zona pellucida-binding protein Sp38 family
    • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus
    text
  • localizes to the acrosome of spermatid (Lin 2007)
  • localization of ZPBP on the extracellular side of both the inner and outer acrosomal membrane during the cap phase of acrosomal development
    • basic FUNCTION
  • with ZPBP2, play cooperative roles during spermiogenesis (Lin 2007)
  • spermatid and spermatozoon protein having a role in sperm-egg interactions (Lin 2007)
  • most prominent protein of the inner acrosomal membrane extracellular coat (IAMC) of spermatozoa
  • role in acrosomal compaction
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGF66
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS