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FLASH GENE
Symbol BRWD1 contributors: - updated : 12-01-2006
HGNC name bromodomain and WD repeat domain containing 1
HGNC id 12760
DNA
TYPE functioning gene
STRUCTURE 128.00 kb     43 Exon(s)
MAPPING cloned Y linked N status provisional
regionally located located within the Down syndrome region-2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 7944 257.2 2269 - Scott (unpublished)
differring from variant 1 at the 3' end including a part of the coding region and the entire UTR, encoding isoform B
- splicing 2488 - 120 - Ramos
lacking multiple 3' exons and having a much shorter and alternate 3' sequence, the encoded isoform C has a much shorter and distinct C-terminus, as compared to isoform A
- - 8670 - 2320 - Scott
isoform A
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eight WD repeats in the N terminal region
  • two C terminal bromodomains
    • HOMOLOGY
    interspecies homolog to murine Brwd1
    Homologene
    FAMILY
  • beta transducin family
  • WD repeat protein family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • cell autonomous regulator oflin-12/notch mediated signaling
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS