Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

TPSG1

contributors: - updated : 08-07-2003

HGNC name	tryptase gamma 1
HGNC id	14134

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	alpha I, beta I, beta II and gamma I (beta I has an allelic variant named alpha II, beta II has an allelic variant beta III and gamma I has an allelic variant gamma II)
STRUCTURE	3.00 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed TPSG1 - - 4929 33.8 321 - Caughey TPSG2 - - 5281 33.8 321 - Caughey TPSG3 - - - - - - Caughey

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine         Endocrine neuroendocrine pituitary       Reproductive male system prostate     moderately Respiratory lung         Skin/Tegument skin         Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective

cells

System Cell Pubmed Species Stage Rna symbol   mast cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains	peptidase S1 domain
	C terminal hydrophobic domain (membrane anchor)

conjugated

GlycoP

mono polymer

polymer

isoforms

Precursor

zymogen

HOMOLOGY

interspecies	ortholog to murine Tpsg1
	homolog to Drosophila CG11192

Homologene

FAMILY	trypsine-like serine protease/prostasine family
	peptidase family S1
	tryptase subfamily

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
text	membrane anchored by a C-terminal hydrophobic domain

basic FUNCTION	serine protease cleaving the Arg-Lys bond (chymotrypsin and trypsin activites)
	implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders

CELLULAR PROCESS

protein, degradation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

heparin-stabilized tetramers

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS