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FLASH GENE

Symbol

TPSG1

contributors: - updated : 08-07-2003

HGNC name	tryptase gamma 1
HGNC id	14134

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	16p13.3      Physical location : 1.271.650 - 1.275.254
Synonym name	serine protease 31
	transmembrane tryptase
	lung tryptase
	mast cell tryptase
	skin tryptase
	pituitary tryptase
Synonym symbol(s)	TMT, PRSS31, trpA
EC.number	3.4.21.59

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	alpha I, beta I, beta II and gamma I (beta I has an allelic variant named alpha II, beta II has an allelic variant beta III and gamma I has an allelic variant gamma II)
STRUCTURE	3.00 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed TPSG1 - - 4929 33.8 321 - Caughey TPSG2 - - 5281 33.8 321 - Caughey TPSG3 - - - - - - Caughey

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine         Endocrine neuroendocrine pituitary       Reproductive male system prostate     moderately Respiratory lung         Skin/Tegument skin         Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective

cells

System Cell Pubmed Species Stage Rna symbol   mast cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains	peptidase S1 domain
	C terminal hydrophobic domain (membrane anchor)

conjugated

GlycoP

mono polymer

polymer

isoforms

Precursor

zymogen

HOMOLOGY

interspecies	ortholog to murine Tpsg1
	homolog to Drosophila CG11192

Homologene

FAMILY	trypsine-like serine protease/prostasine family
	peptidase family S1
	tryptase subfamily

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
text	membrane anchored by a C-terminal hydrophobic domain

basic FUNCTION	serine protease cleaving the Arg-Lys bond (chymotrypsin and trypsin activites)
	implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders

CELLULAR PROCESS

protein, degradation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

heparin-stabilized tetramers

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS