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FLASH GENE
Symbol TOM1L1 contributors: SGE/npt - updated : 26-01-2010
HGNC name target of myb1 (chicken)-like 1
HGNC id 11983
Location 17q22      Physical location : 52.978.051 - 53.039.328
Synonym name
  • Src activating and signaling molecule
  • target of myb1-like 1 (chicken)
  • Synonym symbol(s) SRCASM, OK/KNS-CL.3
    DNA
    TYPE functioning gene
    STRUCTURE 61.28 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    CA10 17q24 carbonic anhydrase X LOC339209 17q22 hypothetical LOC339209 LOC124662 17q22 similar to phosphatidylinositol 4-kinase type II LOC388402 17 similar to 40S ribosomal protein S2 LOC84643 17q22 kinesin protein LOC390803 17 similar to KIAA2033 protein LOC124667 17q22 similar to hypothetical protein MGC4276 similar to CG8198 TOM1L1 22q13 target of myb1-like 1 (chicken) COX11 17q21.31-q23 COX11 homolog, cytochrome c oxidase assembly protein (yeast) STXBP4 17q22 syntaxin binding protein 4 HLF 17q22 hepatic leukemia factor MMD 17q monocyte to macrophage differentiation-associated LOC390804 17 similar to Glycyl-tRNA synthetase (Glycine--tRNA ligase) (GlyRS) LOC342599 17q23.1 similar to PEPD protein FLJ10970 17q23.1 hypothetical protein FLJ10970 PCTP 17q21-q22 phosphatidylcholine transfer protein FLJ38335 17q23.1-q23.2 hypothetical protein FLJ38335 LOC342600 17q23.2 similar to hypothetical protein 4932411E22 NOG 17q22 noggin DGKE 17q22 diacylglycerol kinase, epsilon 64kDa ZNF147 17q22 zinc finger protein 147 (estrogen-responsive finger protein) COIL 17q22-q23 coilin RISC 17q23.2 coilin LOC376412 17q23.2 ring finger protein 126 pseudogene AKAP1 17q21-q23 a kinase (PRKA) anchor protein 1 MSI2 17q23.1 musashi homolog 2 (Drosophila) FLJ11710 17q23.2 hypothetical protein FLJ11710 MRPS23 17q22-q23 mitochondrial ribosomal protein S23 C14orf34 14q23.2 chromosome 14 open reading frame 34 ZNF161 17q23.3 zinc finger protein 161 SFRS1 17q21.3-q22 splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor) Dlc2 17q23.2 dynein light chain 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 2356 - 476 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Hearing/Equilibriumearinnercochlea  
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    Visualeyelacrimal gland   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal VHS (Vps27p/Hrs/Stam) domain
  • a GAT (GGA and Tom1) domain, both of which are also found in the GGA (Golgi-localizing, gamma-adaptin ear domain homology, ADP-ribosylation factor-binding protein) family of proteins
  • HOMOLOGY
    interspecies homolog to murine Tom1l1 (79.2pc)
    intraspecies homolog to TOM1
    Homologene
    FAMILY
  • TOM1 family
  • CATEGORY adaptor , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    text cytosolic TOM1L1 is recruited onto the plasma membrane and subsequently redistributed into the early endosome (Liu 2009)
    basic FUNCTION
  • adapter protein involved in signaling pathways, interacting with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated
  • participating in EGF-stimulated endocytosis of EGF receptor (Liu 2009)
  • may promotes FYN activation
  • involved in the FcepsilonRI signal transduction for the generation of cytokines (Zhang 2007)
  • playing a role in linking EGFR- and SFK-dependent signaling to differentiation in keratinocytes (Li 2005)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with FYN, GRB2 and PIK3R1
  • GAT domains interact with ubiquitin and TOLLIP
  • interacting with the activated EGFR bridged by Grb2 and Shc (Liu 2009)
  • cell & other
  • associates with the midbody during cytokinesis (Yanagida-Ishizaki 2008)
  • REGULATION
    Other phosphorylated upon DNA damage probably by ATM or ATR
    Tyr-phosphorylated by the Src family kinases (Liu 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
  • decreased in the hyperproliferative keratinocytes found in the seborrheic keratoses and basal cell carcinomas (Meulener 2009)
  • Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS