| basic FUNCTION
| cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts |
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may be involved in connections of major cytoskeletal structures to the plasma membrane |
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link the actin cytoskeleton to the extracellular environment through interactions with beta-integrins and actin |
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serves as an essential link between integrins and the actin cytoskeleton in several similar, but functionally distinct, adhesion complexes, including focal adhesions, costameres, and intercalated disks |
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may serve as the link between integrins and the sarcomeric cytoskeletonin stable adhesion complexes in mature striated muscle |
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TLN1, TLN2 are crucial for skeletal muscle development, where they regulate myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions (MTJs)  |
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plays an important role in cell adhesion and recycling of synaptic vesicles |
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adaptor proteins that connect the integrin family of cell adhesion receptors to cytoskeletal actin |
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TLN1 and TLN2 have distinct functions in the myocardium |
