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FLASH GENE

Symbol

SRR

contributors: mct - updated : 01-07-2011

HGNC name	serine racemase
HGNC id	14398

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function aberrant Srr function and diminished d-serine may contribute to schizophrenia pathogenesis constitutional     --over   increased expression in the hippocampus in schizophrenia (

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed psychiatry schizophrenia   promising target for the treatment of disorders related to NMDAR dysfunction

ANIMAL & CELL MODELS

	mutant Srr mice displayed behaviors relevant to schizophrenia, including impairments in prepulse inhibition, sociability and spatial discrimination