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FLASH GENE
Symbol SEMA6A contributors: mct/npt - updated : 15-11-2016
HGNC name sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
HGNC id 10738
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an extracellular semaphorin domain
  • a transmembrane domain
  • a long cytoplasmic tail containing an EVL binding site
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Sema6a
    Homologene
    FAMILY
  • semaphorin family
  • CATEGORY signaling , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • retrograde signaling
  • having a novel function in the cytoskeleton and a playing a role in modulating tubulin isotype composition and microtubule dynamics
  • mediate spatially regulated repulsion within the developing eye to promote eye vesicle cohesion
  • SEMA6A and its receptor PLXNA2 control the ability of migrating granule cells to switch from one mode of migration to the other (tangentially in the external granule cell layer or radially)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    guidance signals in embryo and organogenesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EMA/VASP
  • semaphorin protein families
  • interacting with PLXNA2 (semaphorin-plexin signaling modulates cell migration by controlling centrosome positioning)
  • FARP1 serves as a specific effector of transmembrane SEMA6A and PLXNA4 signals to regulate lateral motor column (LMC) dendritic growth
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in certain forms of lung cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • homozygous mice for an insertion in the semaphorin domain