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FLASH GENE
Symbol NCKIPSD contributors: mct/npt/pgu - updated : 12-06-2010
HGNC name NCK interacting protein with SH3 domain
HGNC id 15486
Location 3p21.31      Physical location : 48.711.279 - 48.723.334
Synonym name
  • SH3 protein fused with HRX (MLL) in therapy-related leukemia with a translocation t(3;11)(p21;q23)
  • SH3 protein interacting with NCK, 90kDa
  • dia interacting protein
  • diaphanous protein interacting protein
  • SH3 adapter protein SPIN90
  • WASP interacting SH3 protein
  • Synonym symbol(s) SPIN90, AF3P21, DIP, DIP1, ORF1, WISH, WASLBP, MGC23891, VIP54
    DNA
    TYPE functioning gene
    STRUCTURE 12.06 kb     13 Exon(s)
    regulatory sequence Promoter (TATA box)
    Binding site
    text structure several transcription factor binding sites
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - - - - intermediate filaments 2000 10619843
  • also called VIP54
  • maybe an alternative transcript of AF3P21
  • 13 - 3023 - 722 - 2009 19460367
    13 - 2968 - 715 - 2009 19460367
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Nervousbrainlimbic systemhippocampus highly Homo sapiensAdult
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiensAdult
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text
  • ubiquitous
  • expressed during the early stages of neuronal development
  • PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • a N terminal SH3 domain
  • a proline-rich domain
  • a bipartite nuclear localization signal (NLS)
  • a serine-threonine rich region
  • C terminal hydrophobic region
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY adaptor , protooncogene , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    intracellular,nucleus
    basic FUNCTION
  • playing a role in maintenance of sarcomere structure and/or in the assembly of myofibrils into sarcomere
  • involvement in the regulation of actin cytoskeleton and actin comet tail formation
  • participate in modulation of actin cytoskeleton by binding to a variety of scaffold and signaling molecules
  • key regulator of actin cytoskeletal organization
  • plays a key role in the formation of the membrane protrusions associated with cell motility
  • F-actin binding protein thought to play important roles in regulating cytoskeletal dynamics
  • plays critical roles in controlling growth cone dynamics and neurite outgrowth
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    signal transduction in the nucleus
    a component
  • formation of a NCKIPSD-BAIAP2 complex mediated through direct association of the proline-rich domain (PRD) of NCKIPSD with the SH3 domain of BAIAP2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding FHOD1
  • binding of the C terminus of SPIN90 with both the Arp2/3 complex (actin-related proteins Arp 2 and Arp 3) and G-actin activates the former, leading to actin polymerization
  • BAIAP2 is a binding partner of NCKIPSD
  • interacting with PALLD (interacts with its SH3 domains and SRC and is required for SRC-induced cytoskeletal remodeling)
  • WASL-interacting protein that binds and activates WASL to recruit the Arp2/3 complex in a Cdc42-independent manner
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion translocation    
    with MLL in t(3;11)(p21;q23) in therapy-related leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS