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FLASH GENE
Symbol RABAC1 contributors: mct - updated : 09-09-2020
HGNC name Rab acceptor 1 (prenylated)
HGNC id 9794
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Rabac1
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,Golgi
intracellular,cytoplasm,organelle,endosome
intracellular,cytoplasm,cytosolic,vesicle
text
  • localizes to the Golgi complex, post-Golgi vesicles, lipid rafts, endosomes, and the plasma membrane
    • basic FUNCTION
  • may enhance rotaviral and retroviral assembly
  • roles of RABAC1 in lipid transport and cell migration
  • general regulator of Rab proteins and of membrane traffic
  • plays an important role in vesicular trafficking
  • plays likely an important role in vesicular trafficking between the Golgi and cilia in differentiating and mature rod photoreceptors
  • is a transmembrane protein localized to the early secretory pathway
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • VAMP2 and RAB3A are SNARE proteins that interact with RABAC1
  • is a novel cellular interacting partner for Epstein-Barr virus-encoded oncoprotein, latent membrane protein 1 (TRAF3)
  • SNCA modulates vesicle trafficking through its interaction with RABAC1
  • RABAC1 inhibits the anti-apoptotic activity of BCL2A1 and induces apoptosis in gastric cancer cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS