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FLASH GENE
Symbol RABAC1 contributors: mct - updated : 09-09-2020
HGNC name Rab acceptor 1 (prenylated)
HGNC id 9794
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
endocrinebraindiencephalonpituitary  
Endocrinepancreas   highly
Nervousbrain   highly
Reproductivemale systemprostate  highly
Respiratorylung   highly
Urinarykidney    
Visualeyeretina    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Visualcone photoreceptor Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Rabac1
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,Golgi
intracellular,cytoplasm,organelle,endosome
intracellular,cytoplasm,cytosolic,vesicle
text
  • localizes to the Golgi complex, post-Golgi vesicles, lipid rafts, endosomes, and the plasma membrane
    • basic FUNCTION
  • may enhance rotaviral and retroviral assembly
  • roles of RABAC1 in lipid transport and cell migration
  • general regulator of Rab proteins and of membrane traffic
  • plays an important role in vesicular trafficking
  • plays likely an important role in vesicular trafficking between the Golgi and cilia in differentiating and mature rod photoreceptors
  • is a transmembrane protein localized to the early secretory pathway
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • VAMP2 and RAB3A are SNARE proteins that interact with RABAC1
  • is a novel cellular interacting partner for Epstein-Barr virus-encoded oncoprotein, latent membrane protein 1 (TRAF3)
  • SNCA modulates vesicle trafficking through its interaction with RABAC1
  • RABAC1 inhibits the anti-apoptotic activity of BCL2A1 and induces apoptosis in gastric cancer cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS