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FLASH GENE

Symbol

RABAC1

contributors: mct - updated : 09-09-2020

HGNC name	Rab acceptor 1 (prenylated)
HGNC id	9794

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006423 5 - 750 NP_006414 - 185 - 2019 31003775

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol endocrine brain diencephalon pituitary     Endocrine pancreas       highly Nervous brain       highly Reproductive male system prostate     highly Respiratory lung       highly Urinary kidney         Visual eye retina       Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Visual cone photoreceptor Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Rabac1

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,cytosolic,vesicle
text	localizes to the Golgi complex, post-Golgi vesicles, lipid rafts, endosomes, and the plasma membrane

basic FUNCTION	may enhance rotaviral and retroviral assembly
	roles of RABAC1 in lipid transport and cell migration
	general regulator of Rab proteins and of membrane traffic
	plays an important role in vesicular trafficking
	plays likely an important role in vesicular trafficking between the Golgi and cilia in differentiating and mature rod photoreceptors
	is a transmembrane protein localized to the early secretory pathway

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	VAMP2 and RAB3A are SNARE proteins that interact with RABAC1
	is a novel cellular interacting partner for Epstein-Barr virus-encoded oncoprotein, latent membrane protein 1 (TRAF3)
	SNCA modulates vesicle trafficking through its interaction with RABAC1
	RABAC1 inhibits the anti-apoptotic activity of BCL2A1 and induces apoptosis in gastric cancer cells

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS