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FLASH GENE
Symbol RABAC1 contributors: mct - updated : 09-09-2020
HGNC name Rab acceptor 1 (prenylated)
HGNC id 9794
Location 19q13.2      Physical location : 42.460.833 - 42.463.528
Synonym name
  • prenylated Rab acceptor 1
  • Prenylated Rab acceptor domain family member 1
    • Synonym symbol(s) PRA1, PRAF1, YIP3
    DNA
    TYPE functioning gene
    STRUCTURE 2.64 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 750 - 185 - 2019 31003775
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    endocrinebraindiencephalonpituitary  
    Endocrinepancreas   highly
    Nervousbrain   highly
    Reproductivemale systemprostate  highly
    Respiratorylung   highly
    Urinarykidney    
    Visualeyeretina    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Visualcone photoreceptor Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Rabac1
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • localizes to the Golgi complex, post-Golgi vesicles, lipid rafts, endosomes, and the plasma membrane
    • basic FUNCTION
  • may enhance rotaviral and retroviral assembly
  • roles of RABAC1 in lipid transport and cell migration
  • general regulator of Rab proteins and of membrane traffic
  • plays an important role in vesicular trafficking
  • plays likely an important role in vesicular trafficking between the Golgi and cilia in differentiating and mature rod photoreceptors
  • is a transmembrane protein localized to the early secretory pathway
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • VAMP2 and RAB3A are SNARE proteins that interact with RABAC1
  • is a novel cellular interacting partner for Epstein-Barr virus-encoded oncoprotein, latent membrane protein 1 (TRAF3)
  • SNCA modulates vesicle trafficking through its interaction with RABAC1
  • RABAC1 inhibits the anti-apoptotic activity of BCL2A1 and induces apoptosis in gastric cancer cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS