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FLASH GENE
Symbol RAB23 contributors: mct/pgu - updated : 28-08-2017
HGNC name RAB23, member RAS oncogene family
HGNC id 14263
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • Ras superfamily of GTP-binding proteins
  • RAB guanosine triphosphatase (GTPase) family of vesicle transport proteins
    • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    basic FUNCTION
  • involved in small GTPase mediated signal transduction and intracellular protein transportation
  • participate in central nervous system development
  • acts as a negative regulator of hedgehog (HH) signaling
  • having a function in antagonizing sonic hedgehog signal transduction
  • may play a role in protein turnover in the cilium
  • negatively regulates GLI1 activity in a SUFU-dependent manner
  • is an essential component of the mechanism that transmits asymmetric patterning information from the node to the lateral plate mesoderm (LPM)
  • small guanine nucleotide binding protein that has important effects on physiological signaling from cilia but was not known previously to be essential for ciliary delivery of any cargo
  • dopamine receptors reveal a previously unrecognized mechanism of ciliary receptor targeting and functional role of RAB23 in promoting this process
  • promotes squamous cell carcinoma cells migration and invasion by regulating ITGB1/TIAM1/RAC1 pathway
  • serves as an important oncoprotein in human astrocytoma by regulating cell invasion and migration through RAC1 activity
  • role for RAB23 in transport processes to the primary cilium
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly associates with SUFU and inhibits GLI1 function in a SUFU-dependent manner
  • KIF17 needs to bind to regulatory proteins like RAB23 for its ciliary transport, and RAB23 could mediate the transport of KIF17 to the primary cilium
    • cell & other
  • interaction with cilia
    • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ACPS2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in primary gastric tumors
    tumoral     --over  
    in Prostate cancer tissues and cell lines
    tumoral     --over  
    facilitates malignant cell growth and invasion in bladder cancer through the NFKB1 pathway
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • could serve as a biomarker that indicates the severity of FSGS
  • RAB23 expression is a useful indicator of metastatic potential for pancreatic duct adenocarcinoma
    • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    is a potential therapeutic target for PCa treatment
    cancerendocrinepancreas
    may be a new therapeutic target for pancreatic duct adenocarcinoma
    ANIMAL & CELL MODELS