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FLASH GENE
Symbol PUM1 contributors: mct/npt - updated : 22-06-2014
HGNC name pumilio homolog 1 (Drosophila)
HGNC id 14957
Location 1p35.2      Physical location : 31.404.352 - 31.538.564
Synonym name pumilio 1
Synonym symbol(s) PUMH1, PUML1, KIAA0099, PUMH, HSPUM
DNA
TYPE functioning gene
STRUCTURE 134.21 kb     22 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC388614 1 LOC388614 LOC388615 1 LOC388615 MATN1 1p35.1-p34.3 matrilin 1, cartilage matrix protein LAPTM5 1p34 matrilin 1, cartilage matrix protein LOC388616 1 LOC388616 SDC3 1pter-p22.3 syndecan 3 (N-syndecan) PUM1 1p35.2 pumilio homolog 1 (Drosophila) SEPW1P 1p34-p35 selenoprotein W, 1 pseudogene FLJ12650 1p35.1 hypothetical protein FLJ12650 HPRP8BP 1p35.1 U5 snRNP-specific 40 kDa protein (hPrp8-binding) PS1D 1p35.1 putative S1 RNA binding domain protein FABP3 1p33-p32 fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) TDE2L 1p35.1 tumor differentially expressed 2-like LOC127572 1p35.1 similar to elongation factor 1 alpha LOC149086 1p35.1 hypothetical protein LOC149086 LCN7 1p34.3 lipocalin 7 HCRTR1 1p33 hypocretin (orexin) receptor 1 PEF 1p34 hypocretin (orexin) receptor 1 COL16A1 1p34.3 collagen, type XVI, alpha 1 BAI2 1p35 brain-specific angiogenesis inhibitor 2 FLJ25348 1p35.1 hypothetical protein FLJ25348 PTP4A2 1p36 protein tyrosine phosphatase type IVA, member 2 KHDRBS1 1p32 KH domain containing, RNA binding, signal transduction associated 1 FLJ10315 1p34.3 hypothetical protein FLJ10315 KPNA6 1p35-p34.1 karyopherin alpha 6 (importin alpha 7) DKFZp451J0118 1p34.3 taxilin
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
22 - 5416 127 1188 - -
22 - 5410 126.3 1186 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • RNA binding domain
  • pumilio-homology domain (PUM-HD)
  • HOMOLOGY
    interspecies homolog to Drosophila pumilio
    Homologene
    FAMILY
  • Puf family of RNA-binding proteins
  • CATEGORY chaperone/stress , regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • developmental regulator controlling mRNA stability and translation
  • could also play an important role in translational regulation of embryogenesis and cell development and differentiation (Spassov 2002)
  • PUM1 and PUM2 repress the translation of E2F3 by binding to the E2F3 3prime untranslated region (UTR) and also enhance the activity of multiple E2F3 targeting microRNAs
  • PUM1, PUM2 regulates the translation of the voltage-gated sodium conductance, leading to a concomitant adjustment in action potential firing
  • PUM1, PUM2 are potent repressors that serve important roles in stem cell maintenance, neurological processes, and embryonic development
  • conserved function of the PUM1, PUM2 RBD is to bind specific mRNAs, antagonize PABPC1 function, and promote deadenylation
  • PUM1, PUM2 increased double-stranded (ds) RNA binding affinity of DHX58, and likely facilitates viral RNA recognition by DHX58 through its chaperon-like function
  • plays an important role in the establishment of the primordial follicle pool, meiosis, and female reproductive competency
  • CELLULAR PROCESS protein, editing
    protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • PUM1 and PUM2 repress the translation of E2F3 by binding to the E2F3 3prime untranslated region (UTR) and also enhance the activity of multiple E2F3 targeting microRNAs
  • RBFOX1 targets PUM1 mRNA for destabilization and translational silencing, thereby promoting germ cell development
  • facilitates the transition of the late meiotic prophase I oocyte from pachytene to diplotene stage by regulating SYCP1 protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS