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FLASH GENE

Symbol

PTPN23

contributors: mct/npt - updated : 05-06-2019

HGNC name	protein tyrosine phosphatase, non-receptor type 23
HGNC id	14406

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	32.46 kb     25 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_015466 25 - 5302 NP_056281 179 1636 - 2007 17959146 NM_001304482 24 - 5174 NP_001291411 - 1510 - 2007 17959146

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node       highly Nervous brain       highly Homo sapiens   nerve       highly Respiratory respiratory tract larynx     highly

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal domain similar to yeast BRO1, AIP1 and rhophilin
	"Zn-hand" domain containing several SH3-binding motif
	a tyrosine phosphatase domain
	a C terminal PEST motif

HOMOLOGY

interspecies	homolog to rattus Ptp-td4
	ortholog to S. cerevisiae Bro1p

Homologene

FAMILY	protein-tyrosine phosphatase family
	non-receptor class subfamily

CATEGORY

enzyme , receptor membrane phosphatase

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,cytosolic,vesicle
	intracellular,cytoplasm,cytoskeleton,microtubule
	intracellular,nucleus,nucleoplasm,nuclear bodies
text	PTPN23, like SMN, shuttles between nucleus and cytoplasm

basic FUNCTION	having a role in modulating endothelial motility
	contributes to the regulation of endothelial motility by modulating the tyrosine phosphorylation of PTK2
	key regulator of endocytic trafficking in which ESCRT-III binding is important but not strictly essential
	participates to the regulation of endothelial motility through its interactions with Src and PTK2
	catalytically inactive protein tyrosine phosphatase
	essential requirement for early stages of embryonic development
	non-transmembrane protein tyrosine phosphatase which contributes to the signal transduction pathways involved in the regulation of cell migration and invasion
	affects the intracellular sorting of activated PDGFRB and the migration, proliferation and tumorigenicity of cells stimulated by PDGF
	is a prominent haploinsufficient tumor suppressor gene preventing tumor progression through control of integrin trafficking
	selectively regulates synaptic neuropeptide release
	expressed non-receptor type, catalytically inactive protein-tyrosine phosphatase found in all cells including neurons

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	binds Focal Adhesion Kinase (PTK2), a crucial regulator of cell migration
	binds CHMP4B via its Bro1 domain, and TSG101 via a central domain that contains two PS/TAP motifs and other proline-rich sequences
	interaction of PTPN23 with two adapters of the GRB2 family, essential for numerous signaling pathways, suggesting that PTPN23 might be important for signaling through a plethora of receptors
	evolutionarily conserved function of PTPN23-RAB4A in the regulation of endocytic trafficking, cell adhesion and migration
	is a central coordinator of the ESCRT pathway for EGFR
	specific interaction between PTPN23 and the ESCRT-I subunit UBAP1 critical for degradation of growth factor receptors and integrins
	ZFYVE9, ZFYVE16 recruit the tumor supressor PTPN23, a master regulator of endosomal sorting and ESCRT-dependent receptor downregulation

cell & other

REGULATION

Other	differentially modulated by two angiogenic growth factors
	degraded by calpains in a calcium-dependent manner, resulting in the acquisition of a more aggressive phenotype in neoplastic cells

ASSOCIATED DISORDERS

corresponding disease(s)

EIEE92

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   loss of PTPN23 may increase the activity of SRC and the phosphorylation status of the CDH1/CTNNB signaling complex to promote tumor growth and invasive behavior in breast cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS