protein
| interacted with harmonin USH1C (probably play a role in disk morphogenesis) |
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interact CDH23 to form a filament with structural similarity to tip links, in sensory hair cells |
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CDH23 and PCDH15 interact to form tip links, which gate mechanotransduction channels in hair cells of the inner ear (Elledge 2010) |
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cytoplasmic N-terminus of HCN1 binds the cytoplasmic C-terminus of stereociliary tip-link protein PCDH15 |
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is an integral component of the hair cells mechanotransduction machinery that functionally couples PCDH15 to the transduction channel |
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CDH23, PCDH15 bind tip-to-tip in a "handshake" mode that involves the EC1 and EC2 repeats ofCDH23, PCDH15 |
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PCDH15 interacts with transmembrane channel-like proteins TMC1 and TMC2 |
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both LHFPL5 and TMC1 were shown to interact with PCDH15, a component of the tip link, which applies force to the mechanotransducer (MT) channel |
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interaction of MYO3A with the cytosolic tail of the integral tip-link protein protocadherin 15 (PCDH15), a core component of MET complex |
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GOPC, a Golgi-associated, PDZ domain-containing protein, interacts with PCDH15 |
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CDH23 and PCDH15, interact in a Ca2+-dependent manner to form tip links |
| Ames waltzer a recessive mutation in mice causes deafness and a balance disorder associated with the degeneration of inner ear neuroepithelia | |
Digenic heterozygotes mice for cadherin 23 and protocadherin 15 display a significant levels of hearing loss, cytoarchitectural defects in the cochlea, degeneration of the stereocilia and a base-apex loss of hair cells and spiral ganglion cells |
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Pcdh15-CD2-deficient mice are deaf, lack kinociliary links and have abnormally polarized hair bundles |
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noddy homozygotes lack inner ear function, and noddy mutant mice harbor an isoleucine-to-asparagine (I108N) mutation in the EC1 repeat of Pcdh15 |