SUBCELLULAR LOCALIZATION
| intracellular
|
|
| intracellular,cytoplasm,organelle,membrane
|
|
| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
|
| intracellular,cytoplasm,organelle,Golgi
|
|
| intracellular,cytoplasm,cytosolic,microsome
|
|
| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
|
|
| intracellular,nucleus
|
| text
| in the centrosome during the mitosis |
|
expressed in the axoplasm and concentrated at synapses |
|
closely co-localized with CEP250 at the proximal ends of centrioles  |
|
an important protein at the interface between the Golgi apparatus and the membrane trafficking machinery mediated by coatomer (COPI)-coated vesicles, and cytoplasmic component of the nuclear tRNA export machinery |
| basic FUNCTION
| involved in centrosome-related cellular function |
|
involved in intracellular transport processes |
|
playing an essential role for neuronal and Purkinje cell survival |
|
accessory factor in coatomer I (COPI) coats trafficking and suggest for the first time that alterations in the COPI pathway result in neurodegenerative disease |
|
transcriptional regulator, activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes (Zhao 2005) |
|
functions as a centrosome regulator and is involved in DNA damage response, including telomere dysfunction and tumorigenesis (Gong 2009) |
|
is required for the maintenance of Golgi morphology |
|
conserved N-terminal protein kinase-like domain protein that plays a role in COP1-mediated retrograde protein trafficking in mammalian cells |
|
is a key regulator of motor neuron survival |
|
functions as a scaffold for key components of COPI coats, and disruption of the scaffolding function of Scyl1 causes tubulation of the endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC) |
|
distributes in the centrosomes and regulates centrosome status under both physiologic and pathologic conditions |
|
closely co-localized with CEP250 at the proximal ends of centrioles, and centriolar loading of SCYL1 stimulated by EGF/AKT could displace CEP250, resulting in centrosome splitting |
|
is involved in vital intracellular transport processes, which might provide a basis for understanding the molecular mechanism underlying disease states caused by loss of SCYL1 |
