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FLASH GENE

Symbol

NOX4

contributors: mct - updated : 05-01-2017

HGNC name	NADPH oxidase 4
HGNC id	7891

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in vascular smooth muscle cells exposed to hypoxia and in lungs from patients with idiopathic pulmonary arterial hypertension

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed diabete     primary target for the design of new therapeutic strategies to counteract oxidant-mediated deleterious effects associated with various diseases characterized by oxidative stress cardiovascular aquired heart failure could be a target of future treatments for heart failure respiratory lung   might be a target for the treatment of pulmonary fibrosis dermatology skin   targeting TGFB1 downstream via the profibrotic mediator NOX4 could be a potential anti-fibrotic therapy

ANIMAL & CELL MODELS

	In a rat model of diabetes, mitochondrial Nox4 expression is increased in kidney cortex (Block 2009)
	in c-Nox4(-/-) mice, reduced levels of O(2)(-) in the heart, indicating that Nox4 is a significant source of O(2)(-) in cardiac myocytes
	Nox4-null mice developed exaggerated contractile dysfunction, hypertrophy, and cardiac dilatation during exposure to chronic overload whereas Nox4-transgenic mice were protected