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FLASH GENE

Symbol

NGB

contributors: mct/npt - updated : 02-12-2015

HGNC name	neuroglobin
HGNC id	14077

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   in astrocytoma tumoral     --over   hypoxic up-regulation of CYGB/NGB in glioblastoma multiforme cell lines and tumor tissues constitutional     --over   in early and moderately advanced Alzheimer disease compared to controls, but declined to control levels in severe disease

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurosensorial visual anterior chamber manipulating the expression and bioactivity of NGB may represent a novel therapeutic strategy for glaucoma neurosensorial visual   should be considered when developing therapeutic strategies for treatment of hypoxia-related ocular diseases neurology neurodegenerative alzheimer may attenuate tau hyperphosphorylation through activating Akt signaling pathway, implying a therapeutic target for AD

ANIMAL & CELL MODELS