| basic FUNCTION
| increasing the availability of oxygen in brain tissues |
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involved in neuroprotection under oxidative stress conditions such as ischemia and reperfusion (GDI activity is tightly correlated with its neuroprotective activity) |
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playing a role in neuronal oxygen homeostasis and hypoxia protection |
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NGB and CYGB may serve a neuroprotective role as scavengers of reactive oxygen species  |
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hexacoordinate globin expressed in the nervous system of vertebrates, where it protects neurons against hypoxia |
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may confer protection against ischemia-reperfusion injury in the brain through its intrinsic antioxidant properties |
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role in nitric oxide signalling for CYGB and involvement in sleep-wake cycling for CYGB and NGB |
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may function as a physiological oxidative stress sensor and a post-translationally redox-regulated nitrite reductase that generates NO under six-to-five-coordinate heme pocket control |
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under hypoxic conditions neuroglobin can inhibit mitochondrial respiration in the presence of nitrite |
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potential role of DNA methylation in regulating NGB tissue-specific expression |
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exerts significant neuroprotective effects after mechanical injury, and thus has important implications for the prognosis and cure of traumatic brain injury |
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may regulate neuronal survival under hypoxia or oxidative stress |
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may modulate retinal ganglion cells susceptibility to glaucomatous neural damage |
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characterized heme globin that is widely expressed in the vertebrate central and peripheral nervous system as well as retina and endocrine tissues |
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globin protein that is highly and specifically expressed in brain neurons |
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neuroprotective molecule against hypoxic/ischemic brain injury and other related neurological disorder |
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pivotal role of neuroglobin in retinal glia involved in neuronal support and/or healing |
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plays an important role in neuronal death upon ischemia and oxidative stress |
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critical role in neuritogenesis or development via interacting with PTEN and AKT1 differentially to activate phosphatidylinositol 3-kinase/AKT1 pathway |
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promotes neuron survival under hypoxic/ischemic conditions |
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NGB signal differentiates the central projections of the inner and outer hair cells |
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NGB can bind to mitochondrial complex III subunit CYC1, leading to suppression of oxygen-glucose deprivation-mediated complex III activity and subsequent ROS production elevation |
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anti-apoptotic property of NGB may play a neuroprotective role against Alzheimer disease |
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displayed a neuron restricted expression pattern in mammalian brains |
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may participate in defense mechanisms in inner ear pathologies where oxidative stress is involved. |
