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FLASH GENE
Symbol NDRG4 contributors: mct - updated : 15-01-2010
HGNC name NDRG family member 4
HGNC id 14466
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
glioblastoma multiforme (GBM) cells
Susceptibility
Variant & Polymorphism
Candidate gene candidate tumor suppressor gene in colorectal cancer whose expression is frequently inactivated by promoter methylation and promoter methylation is a potential biomarker for the noninvasive detection of colorectal cancer
Marker
Therapy target
ANIMAL & CELL MODELS
Tbx2 in the embryonic mouse heart at early stages of development throughout the myocardium of the heart tube both represses proliferation and impairs secondary heart field (SHF) progenitor cell deployment into the outflow tract (OFT), implicating the upregulation of Ndrg2 and downregulation of Ndrg4 expression