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FLASH GENE
Symbol NDRG4 contributors: mct - updated : 15-01-2010
HGNC name NDRG family member 4
HGNC id 14466
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus bdm1
intraspecies homolog to NDRG1
homolog to NDRG2 (60p1000)
Homologene
FAMILY N-Myc downstream-regulated gene (NDRG) family
CATEGORY regulatory , signaling hormone
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • may be playing a role in the early postnatal development and function of neuronal cells
  • may play a role in supporting the activation of ERK and its target proteins needed for neuronal differentiation and in reducing the activation of ELK1 implicated in cell growth
  • essential role in regulating proliferation and growth of cardiomyocytes, suggesting that it may function downstream of TBX5 during heart development and growth
  • may play a partially redundant role in specific cells in the brain
  • required for cell cycle progression and survival, thereby diverging in function from its tumor suppressive family member NDRG2 in astrocytes and glioblastoma multiforme (GBM)cells
  • presence of NDRG4 is required for the viability of GBM cell populations and primary astrocytes and in GBM cells, required for continued progression through the cell cycle and ultimately for survival
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    glioblastoma multiforme (GBM) cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate tumor suppressor gene in colorectal cancer whose expression is frequently inactivated by promoter methylation and promoter methylation is a potential biomarker for the noninvasive detection of colorectal cancer
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Tbx2 in the embryonic mouse heart at early stages of development throughout the myocardium of the heart tube both represses proliferation and impairs secondary heart field (SHF) progenitor cell deployment into the outflow tract (OFT), implicating the upregulation of Ndrg2 and downregulation of Ndrg4 expression