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FLASH GENE

Symbol

NDRG4

contributors: mct - updated : 15-01-2010

HGNC name	NDRG family member 4
HGNC id	14466

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	16q21      Physical location : 58.497.548 - 58.547.522
Synonym name	smooth muscle-associated protein 8
	brain development-related molecule 1
	vascular smooth muscle cell-associated protein 8
Synonym symbol(s)	KIAA1180, SMAP8, FLJ30586, FLJ42011, BDM1, DKFZp686I1615, MGC19632

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem
STRUCTURE	49.97 kb     16 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 5 - splicing 3160 isoform 5 37.08 339 only in brain (neurons of brain, spinal cord) 2001 11352569 also called NDRG4B variant 4 - splicing 3190 isoform 4 38.45 352 minor expression 2001 11352569 also called NDRG4BV NM_020465 16 splicing 3356 NP_065198 40.64 371 both brain and heart 2009 19592488 also called NDRG4H, isoform 1 NM_001130487 16 - 3581 NP_001123959 - 391 - 2009 19592488 also called variant 2 NM_022910 16 - 3414 NP_075061 - 371 - - also called variant 3

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Homo sapiens Nervous brain hindbrain cerebellum     Homo sapiens   nerve       highly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Nervous Purkinje cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

cell cycle

cell cycle

Text

brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to rattus bdm1

intraspecies	homolog to NDRG1
	homolog to NDRG2 (60p1000)

Homologene

FAMILY

N-Myc downstream-regulated gene (NDRG) family

CATEGORY

regulatory , signaling hormone

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	may be playing a role in the early postnatal development and function of neuronal cells
	may play a role in supporting the activation of ERK and its target proteins needed for neuronal differentiation and in reducing the activation of ELK1 implicated in cell growth
	essential role in regulating proliferation and growth of cardiomyocytes, suggesting that it may function downstream of TBX5 during heart development and growth
	may play a partially redundant role in specific cells in the brain
	required for cell cycle progression and survival, thereby diverging in function from its tumor suppressive family member NDRG2 in astrocytes and glioblastoma multiforme (GBM)cells
	presence of NDRG4 is required for the viability of GBM cell populations and primary astrocytes and in GBM cells, required for continued progression through the cell cycle and ultimately for survival

CELLULAR PROCESS	cell life, differentiation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

hormonal

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   glioblastoma multiforme (GBM) cells

Susceptibility

Variant & Polymorphism

Candidate gene	candidate tumor suppressor gene in colorectal cancer whose expression is frequently inactivated by promoter methylation and promoter methylation is a potential biomarker for the noninvasive detection of colorectal cancer
Marker
Therapy target

ANIMAL & CELL MODELS

Tbx2 in the embryonic mouse heart at early stages of development throughout the myocardium of the heart tube both represses proliferation and impairs secondary heart field (SHF) progenitor cell deployment into the outflow tract (OFT), implicating the upregulation of Ndrg2 and downregulation of Ndrg4 expression