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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

GAPDH

contributors: mct/shn - updated : 22-08-2017

HGNC name	glyceraldehyde-3-phosphate dehydrogenase
HGNC id	4141

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   amplification     in Huntington disease (high molecular weight protein) tumoral     --over   in gastric cancer tumoral   translocation     with BCL6 in primary diffuse large B-cell lymphomas of the central nervous system tumoral     --over   overexpressed in renal cell carcinoma constitutional     --over   in apoptosis and in several chronic pathologies

Susceptibility

to late-onset Alzheimer disease

Variant & Polymorphism SNP	SNP increasing the risk of late-onset Alzheimer disease

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed diabete     agents that can directly target modification of GAPDH have potential in inhibiting the development and in arresting the progression of diabetic retinopathy cancer digestive pancreas double blockade of GAPDH and mitochondrial respiration could be a novel strategy for the treatment of PRMT3-overexpressing pancreatic cancer

ANIMAL & CELL MODELS