Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CKM contributors: npt/mct - updated : 30-08-2010
HGNC name creatine kinase, muscle
HGNC id 1994
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , heteromer , dimer
HOMOLOGY
interspecies ortholog to rattus Ckm
ortholog to murine Ckm
homolog to zebrafish ckm
Homologene
FAMILY
  • atp:guanido phosphotransferase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text
  • restricted to terminally differentiated striated muscle
    • basic FUNCTION
  • reversibly catalyzing the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate)
  • playing a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa
  • being an important serum marker for myocardial infarction
  • catalyzes the reversible transfer of the gamma phosphate from ATP to creatine forming the high energy compound creatine phosphate (Nuss 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text energy homeostasis
    PATHWAY
    metabolism energetic
    signaling
    a component
  • homodimerizing or heterodimerizing with CKB
    • (M and B are the type of subunit)
  • MM being the major form in skeletal muscle and myocardium
  • MB existing in myocardium
  • BB existing in many tissues, especially brain
    • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
    • protein
  • interacting with KLF3 (likely that KLF3 serves as a positive regulator of muscle gene transcription)
  • physically interact with the slow skeletal muscle-type MYBPC1 (CKM binds to the C-terminal domains of MYBPC1, which is also the binding site of myosin)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    with Jun-D, myogenin, myosin, in muscle wasting of human cachexia (Ramamoorthy 2009)
    constitutional     --low  
    early down-regulation plays a major role in actin filament instability
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS