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FLASH GENE
Symbol LZTS1 contributors: mct/npt - updated : 08/10/2008
HGNC name leucine zipper, putative tumor suppressor 1
HGNC id 13861
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a leucine-zipper region
    • HOMOLOGY
    Homologene
    FAMILY
  • leucine-zipper protein family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    basic FUNCTION
  • inhibits cancer cell growth through regulation of mitosis, and its alterations result in abnormal cell growth
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other hyperphosphorylated by cAMP-dependent kinase during cell-cycle progression
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    in prostate carcinoma, transitional cell carcinoma of the bladder
    tumoral   LOH    
    in oral squamous cell carcinomas
    tumoral        
    silenced in rapidly metastasizing and metastatic uveal melanomas but not in slowly metastasizing and nonmetastasizing uveal melanomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS