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FLASH GENE
Symbol LPIN3 contributors: mct/npt - updated : 20-12-2016
HGNC name lipin 3
HGNC id 14451
Location 20q11.2-q12      Physical location : 39.969.559 - 39.989.221
Synonym name lipin 3-like
Synonym symbol(s) LIPN3L, RP4-620E11.3, SMP2, dJ450M14.2, dJ450M14.3, dJ620E11.2
DNA
TYPE functioning gene
SPECIAL FEATURE head to head
STRUCTURE 19.66 kb     20 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
20 - 4464 93.5 851 - Deloukas (2001)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
 liver    
Reproductivemale systemtestis   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
not specificadipocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-LIP and C-LIP domains exhibit conservation between family members
  • P, serine residue 106, which is known to be phosphorylated in response to insulin
  • a NLS, nuclear localization signal
  • DXDXT, PAP1 enzyme active site
  • LXXIL, transcription factor interaction domain
  • mono polymer heteromer , oligo
    HOMOLOGY
    intraspecies homolog to LPIN1
    homolog to LPIN2
    Homologene
    FAMILY
  • lipin family
  • Mg2+-dependent phosphatidate phoshatases (PAP1 enzymes)family
  • conserved haloacid dehalogenase superfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    intracellular,nuclear envelope
    text lipid phosphatase enzyme at the endoplasmic reticular membrane, that can rapidly translocate within the cell
    basic FUNCTION
  • required for normal adipose tissue development
  • having a role likely to carry out similar functions in glycerolipid biosynthesis and gene expression in a distinct tissue distribution
  • also play crucial roles in the nucleus as transcriptional regulatory proteins
  • lipin 1, 2, and 3 are bifunctional intracellular proteins that regulate metabolism by acting as coregulators of DNA-bound transcription factors and also dephosphorylate phosphatidate to form diacylglycerol
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    triglyceride metabolism
    a component lipin proteins function as oligomeric complexes and that the three mammalian lipin isoforms can form combinatorial units
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with CTDNEP1 (Lipin cellular location, protein partners, and biological function are directed by phosphorylation-dephosphorylation events catalyzed by the phosphoserine phosphatase CTDNEP1)
    cell & other
    REGULATION
    induced by differentiation of preadipocytes
    Other dephosphorylated by CTDNEP1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene lipodystrophy
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • increased liver expression of the LPIN3 gene has been demonstrated in the liver of fld mice and partially compensates for decreased liver PAP1 activity