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FLASH GENE
Symbol LMOD3 contributors: mct - updated : 15-05-2018
HGNC name leiomodin 3 (fetal)
HGNC id 6649
DNA
TYPE functioning gene
STRUCTURE 13.92 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 2221 64.8 560 - 2014 25250574
3 - 2315 64.8 560 - 2014 25250574
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • tropomodulin family
    • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • involved in tropomyosin binding
  • appropriate levels of both TMOD4 and LMOD3 are required for embryonic myofibrillogenesis and, both proteins can function redundantly during skeletal muscle thin filament assembly
  • is required in the fast fibers for sarcomere integrity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TMOD1 and TMOD4 cap thin filament pointed ends and functionally interact with the LMOD isoforms LMOD2 and LMOD3 to control myofibril organization, thin filament lengths, and actomyosin crossbridge formation in skeletal muscle fibers
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NEM10
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Lmod3(PB/PB) mice show severe muscle weakness and postnatal growth retardation