Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol LMOD2 contributors: mct/pgu - updated : 30-06-2011
HGNC name leiomodin 2 (cardiac)
HGNC id 6648
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • putative skeletal muscle TM binding domain region conserved in Tmods
  • central C-terminal conserved region, a unique 150-AA C-terminal extension that is required for its strong nucleating activity
    • HOMOLOGY
    Homologene
    FAMILY
  • tropomodulin family
    • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION
    text
  • Lmod displays dynamic localization to two broader bands, which are generally more separated from M-lines in myofibrils
    • basic FUNCTION
  • contributes to the final organization and maintenance of sarcomere architecture by promoting tropomyosin-dependent actin filament nucleation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • leiomodin/tropomyosin binding is isoform-specific and differs almost 100-fold for different tropomyosin isoforms
  • interacting with TMOD1 (LMOD2 antagonizes the function of TMOD1, and together, these molecules might fine-tune thin filament lengths)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS