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FLASH GENE
Symbol LMOD2 contributors: mct/pgu - updated : 30-06-2011
HGNC name leiomodin 2 (cardiac)
HGNC id 6648
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart     Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
Muscularstriatumcardiac   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Muscularmyocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text heart
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • putative skeletal muscle TM binding domain region conserved in Tmods
  • central C-terminal conserved region, a unique 150-AA C-terminal extension that is required for its strong nucleating activity
    • HOMOLOGY
    Homologene
    FAMILY
  • tropomodulin family
    • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION
    text
  • Lmod displays dynamic localization to two broader bands, which are generally more separated from M-lines in myofibrils
    • basic FUNCTION
  • contributes to the final organization and maintenance of sarcomere architecture by promoting tropomyosin-dependent actin filament nucleation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • leiomodin/tropomyosin binding is isoform-specific and differs almost 100-fold for different tropomyosin isoforms
  • interacting with TMOD1 (LMOD2 antagonizes the function of TMOD1, and together, these molecules might fine-tune thin filament lengths)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS