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FLASH GENE

Symbol

LMOD2

contributors: mct/pgu - updated : 30-06-2011

HGNC name	leiomodin 2 (cardiac)
HGNC id	6648

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	8.29 kb     3 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed LMOD2 3 - 2181 61.54 547 - 2008 18403713

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal     Muscular striatum cardiac     Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Muscular myocyte Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

heart

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	putative skeletal muscle TM binding domain region conserved in Tmods
	central C-terminal conserved region, a unique 150-AA C-terminal extension that is required for its strong nucleating activity

HOMOLOGY

Homologene

FAMILY

tropomodulin family

CATEGORY

motor/contractile

SUBCELLULAR LOCALIZATION
text	Lmod displays dynamic localization to two broader bands, which are generally more separated from M-lines in myofibrils

basic FUNCTION

contributes to the final organization and maintenance of sarcomere architecture by promoting tropomyosin-dependent actin filament nucleation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	leiomodin/tropomyosin binding is isoform-specific and differs almost 100-fold for different tropomyosin isoforms
	interacting with TMOD1 (LMOD2 antagonizes the function of TMOD1, and together, these molecules might fine-tune thin filament lengths)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS