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FLASH GENE
Symbol LHX5 contributors: - updated : 05-09-2007
HGNC name LIM homeobox protein 5
HGNC id 14216
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,chromatin/chromosome
basic FUNCTION
  • regulator of neuronal differentiation and migration during development of the central nervous system
  • playing an essential role for controlling Purkinje cell differentiation in the developing mammalian cerebellum
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    mice Lhx5-/- display severely disorganized brain,impaired cognition and motor coordination