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FLASH GENE
Symbol COG2 contributors: mct - updated : 02-01-2019
HGNC name component of oligomeric Golgi complex 2
HGNC id 6546
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , oligo
HOMOLOGY
interspecies homolog to murine Cog2
Homologene
FAMILY COG2 family
CATEGORY receptor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,Golgi
intracellular,cytoplasm,cytosolic
text cis/medial Golgi
basic FUNCTION
  • critical role in Golgi structure and function
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text tethering intra-Golgi transport vesicle
    PATHWAY
    metabolism carbohydrate
    signaling
    processing of glycoconjugates
    a component
  • component of the conserved oligomeric Golgi complex which is composed of eight different subunits
  • COG complex essentially formed by two subcomplexes, lobe A (COG1-4) and lobe B (COG5-8)
  • COG1, COG2, COG3, COG4, form a stable core complex potentially sufficient to support wild-type growth and reasonably efficient retrograde trafficking
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • USO1 plays an important role in the biogenesis and maintenance of the Golgi by interacting with the COG complex (and COG2) on the cis-Golgi in vesicular trafficking
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG2Q
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS