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FLASH GENE

Symbol

COG2

contributors: mct - updated : 02-01-2019

HGNC name	component of oligomeric Golgi complex 2
HGNC id	6546

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	CDG2Q congenital disorder of glycosylation, type IIQ
Location	1q42.2      Physical location : 230.778.201 - 230.829.730
Synonym name	brefeldin A-sensitive, peripheral Golgi protein
	low density lipoprotein receptor defect C complementing
	conserved oligomeric Golgi complex component 2
Synonym symbol(s)	LDLC

DNA

TYPE	functioning gene
STRUCTURE	51.53 kb     18 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_007357 18 - 2977 NP_031383 - 738 - 2002 11980916 NM_001145036 18 - 2974 NP_001138508 - 737 - 2002 11980916

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel         Digestive mouth         Endocrine parathyroid         Lymphoid/Immune lymph node         Reproductive male system testis

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

heteromer , oligo

HOMOLOGY

interspecies

homolog to murine Cog2

Homologene

FAMILY

COG2 family

CATEGORY

receptor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,cytosolic
text	cis/medial Golgi

basic FUNCTION

critical role in Golgi structure and function

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

text	tethering intra-Golgi transport vesicle

PATHWAY

metabolism

carbohydrate

signaling

processing of glycoconjugates

a component	component of the conserved oligomeric Golgi complex which is composed of eight different subunits
	COG complex essentially formed by two subcomplexes, lobe A (COG1-4) and lobe B (COG5-8)
	COG1, COG2, COG3, COG4, form a stable core complex potentially sufficient to support wild-type growth and reasonably efficient retrograde trafficking

INTERACTION

DNA

RNA

small molecule

protein

USO1 plays an important role in the biogenesis and maintenance of the Golgi by interacting with the COG complex (and COG2) on the cis-Golgi in vesicular trafficking

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CDG2Q

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS