basic FUNCTION
| may help to regulate the strict tissue and nephron segment-specific expression of CLCNKA and CLCNKB channel genes |
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transcriptional repressor of the rhodopsin and IRBP promoters and, in the retina, is a possible participant in repression of photoreceptor-specific gene expression in nonphotoreceptor cells |
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regulated by insulin and contributing to the regulation of PCK2 gene expression in the liver |
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playing an essential role in adipogenesis in cells through its regulation of PPARG expression |
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acting as an essential regulator of cardiac remodeling under stress |
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negative regulator of CTGF expression and cardiac fibrosis |
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implicated in the regulation of adrenomedullin expression in adipose tissu |
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plays a key role in adipocyte differentiation and glucose transport in adipocytes through activation of its target genes |
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having a potential role in the regulation of female testosterone production and fat stores may play a central role in the pathogenesis of polycystic ovary syndrome |
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regulates BMPER in endothelial cells |
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plays an important role in the transcriptional regulation of genes during adipogenesis |
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robustly inhibits myocardin, a potent transcriptional activator |
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acts a transcriptional repressor of pathological cardiac hypertrophy |
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acting as a potent competitive inhibitor of myocardin, thereby preventing transcription of SRF target genes |
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KLF11 and KLF15 enhanced UCP1 expression level during brown adipocyte differentiation through their direct interaction with specific binding domains of the UCP1 promoter |
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play an important role in the regulation of gluconeogenesis |
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serves as a molecular link between myogenic factors and the activity of the D4Z4 enhancer, and it thus contributes to the overexpression of the DUX4L9 and FRG2 genes during normal myogenic differentiation and in FSHMD1A |
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required to activate the D4Z4 enhancer in proliferating myoblasts |
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controls FRG2 expression without affecting myogenic differentiation |
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possible role of KLF15 in D4Z4 enhancer activation during myogenic differentiation |
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directly regulates a broad transcriptional program spanning all major segments of the lipid-flux pathway in muscle |
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is a direct transcriptional regulator of the lipid-flux pathway |
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kidney-enriched nuclear transcription factor, that has been previously shown to mediate cell differentiation |
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critical role of KLF15 in mediating podocyte differentiation and in protecting podocytes against injury |
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is a downstream physiological mediator of progesterone cell cycle inhibitory action in the uterine epithelium |
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is a negative regulator of cell proliferation in hormone responsive cell lines, at least in part through its inhibition of MCM2 transcription |
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is an important molecular link between ER stress and insulin action |
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essential mediator of ER stress-induced insulin resistance in the liver |
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plays an important role and may prove to be an antifibrotic factor in renal interstitial fibrosis through regulation of ERK/MAPK and JNK/MAPK signaling pathways |
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is a key regulator of myocardial lipid utilization and is the first to implicate the KLF transcription factor family in cardiac metabolism |
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is a nodal connection between the clock and meaningful rhythmicity in the heart |
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transcription factor family that plays a critical role in regulating renal fibrosis |