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FLASH GENE
Symbol IL23A contributors: mct - updated : 02-06-2015
HGNC name interleukin 23, alpha subunit p19
HGNC id 15488
Location 12q13.2      Physical location : 56.732.662 - 56.734.193
Synonym name JKA3 induced upon T-cell activation
Synonym symbol(s) P19, SGRF, IL23P19, IL23, IL-23, IL-23A
DNA
TYPE functioning gene
STRUCTURE 6.25 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
motif Viral sequence   long terminal repeat
text structure specific HERV-K LTR 6 kb upstream
MAPPING cloned Y linked N status provisional
Physical map
ZNFN1A4 12q13 zinc finger protein, subfamily 1A, 4 (Eos) RPS26 12q14 ribosomal protein S26 ERBB3 12q13.3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) PA2G4 12q13 proliferation-associated 2G4, 38kDa RPL41 12q14 ribosomal protein L41 FLJ14451 12q13.13 hypothetical protein FLJ14451 MBC2 12q13.13 hypothetical protein FLJ14451 MLC1SA 12q13.13 hypothetical protein FLJ14451 MYL6 12q12 myosin, light polypeptide 6, alkali, smooth muscle and non-muscle SMARCC2 12q13-q14 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 RNF41 12q13.13 ring finger protein 41 MGC2731 12q13.13 hypothetical protein MGC2731 SLC39A5 12q13.3 solute carrier family 39 (metal ion transporter), member 5 FLJ34236 12q13.13 hypothetical protein FLJ34236 FLJ32452 12q13.13 hypothetical protein FLJ32452 CS 12p11-qter citrate synthase TMEM4 12q15 transmembrane protein 4 USP52 12q13.2-q13.3 ubiquitin specific protease 52 APOF 12q13.13 apolipoprotein F IL23A 12q13.2-q13.3 interleukin 23, alpha subunit p19 STAT2 17q11.1-q22 signal transducer and activator of transcription 2, 113kDa LOC390331 12 similar to hypothetical protein FLJ10560 TIMELESS 12q12-q13 timeless homolog (Drosophila) MIP 12q13 major intrinsic protein of lens fiber LOC283377 12q13.13 hypothetical protein LOC283377 GA 12q13 hypothetical protein LOC283377 LOC338801 12q13.13 similar to 60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) (HuCHA60) RBMS2 12q12 RNA binding motif, single stranded interacting protein 2 BAZ2A 12q24.3-qter bromodomain adjacent to zinc finger domain, 2A
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1049 - 189 - -
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach     Homo sapiens
Lymphoid/Immunelymph node    
Respiratorylung    
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveepithelial cell Homo sapiens
Lymphoid/Immunemacrophage
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four alpha helices
  • five cysteines residues
  • secondary structure four alpha helices
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Il23a
    ortholog to rattus Il23a
    Homologene
    FAMILY IL12 family of heterodimeric cytokines
    CATEGORY immunity/defense , signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    text secreted
    basic FUNCTION
  • activating the transcription activator STAT4, and stimulating the production of interferon-gamma (IFNG)
  • preferentially acting on memory CD4(+) T cells
  • playing a role in psoriasis
  • may have antitumor and antimetastatic activity
  • initiates and perpetuates both innate and T cell-mediated intestinal inflammation
  • mediates late-stage inflammation and seems to be necessary for chronic inflammation
  • plays a critical role in promoting the proliferation of memory T helper 1 cells
  • multiple functions of IL23A signaling in T cells that contribute to its colitogenic activity
  • critical functional role for IL23A in psoriasis
  • IL17A/IL23A may play a crucial role in autoimmune diseases
  • plays an important role in the pathogenesis of ulcerative colitis
  • autophagy has a potentially pivotal role to play in the induction and regulation of inflammatory responses by innate immune cells, largely driven by IL1A, IL1B and its consequential effects on IL23A secretion
  • possible involvement of IL23A in the pathogenesis of polycythemia vera (PV)
  • IL1A and IL23A signaling seems to be closely regulated through MYD88 in both innate and adaptive immune cells
  • essential for the differentiation of pathogenic effector T helper 17 (Th17) cells, and in primary and memory Th17 cell responses operates via regulation of proliferation-associated pathways
  • IL23A and IL17A may play an important role in the pathogenesis of primary biliary cirrhosis (PBC) by promoting inflammation
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    PATHWAY
    metabolism
    signaling
    a component
  • subunit of the heterodimeric cytokine interleukine 23 (IL12RB1/IL23A)
  • is a binary complex of a four-helix bundle cytokine (p19) and a soluble class I cytokine receptor p40
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IL12RB1
  • IFNG (stimulation of IFNG)
  • MYD88-dependent Toll-like receptor signaling induces IL23A gene expression through both MAPKs and NF-kappaB
  • autophagy regulates IL23A secretion and innate T cell responses through effects on IL1B secretion
  • MYD88 plays a critical role in integrating IL1A and IL23A signaling for Th17 cell proliferation and expansion
  • MMP9 inhibits IL23A expression in dendritic cells by targeting membrane stem cell factor affecting lung IL17 response
  • IL23A is a RUNX3 target gene in gastric epithelial cells
  • cell & other
    REGULATION
    induced by IL1B and TNF-alpha in colonic myofibroblasts
    inhibited by PPP2CA inhibiting IL23A production by suppressing the expression of the IL23A gene
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    increased levels in psoriatic lesions
    tumoral     --over  
    in human tumours
    constitutional     --over  
    serum IL23A levels were increased in patients with ulcerative colitis compared to normal controls
    Susceptibility
  • to Crohn disease
  • to rheumatoid arthritis
  • Variant & Polymorphism SNP increasing the risk of Crohn disease
    Candidate gene
    Marker
    Therapy target antibodies specific as therapeutic targets in rheumatoid arthritis
    SystemTypeDisorderPubmed
    dermatologyskin 
    targeting IL-23 might be a more selective, valid and effective therapeutic approach, which, potentially, may show important advantages in terms of long-term efficacy and safety in the treatment of psoriasis
    immunologyinflammatory 
    targeting IL-23 pathway may combat inflammation-driven bone destruction as observed in rheumatoid arthritis and other autoimmune arthritides
    ANIMAL & CELL MODELS
  • mice transgenic for ubiquitous expression of IL23A showed multi-organs inflammation, elevated serum levels of IL1 and TNF, chronic expression of hepatic acute phase proteins, anemia, runting, premature death and infertility
  • mice p19-/- or p40-/- are resistant to experimental allergic encephalomyelitis. Myelin oligodendrocyte glycoprotein immunization induced Th1 cells and proinflammatory cytokines in p19-/- mice
  • Il23a(-/-) exhibit increased bacterial growth late in infection that is temporally associated with smaller B cell follicles in the lungs
  • in Mmp9(-/-) mice, a Th1-inducing condition could maintain membrane-bound stem cell factor (mSCF) and enhance Il23 in dendritic cells promoting IL17-producing CD4(+) T cells in the lung