basic FUNCTION
| activating the transcription activator STAT4, and stimulating the production of interferon-gamma (IFNG) |
|
preferentially acting on memory CD4(+) T cells |
|
playing a role in psoriasis |
|
may have antitumor and antimetastatic activity |
|
initiates and perpetuates both innate and T cell-mediated intestinal inflammation |
|
mediates late-stage inflammation and seems to be necessary for chronic inflammation |
|
plays a critical role in promoting the proliferation of memory T helper 1 cells |
|
multiple functions of IL23A signaling in T cells that contribute to its colitogenic activity |
|
critical functional role for IL23A in psoriasis |
|
IL17A/IL23A may play a crucial role in autoimmune diseases |
|
plays an important role in the pathogenesis of ulcerative colitis |
|
autophagy has a potentially pivotal role to play in the induction and regulation of inflammatory responses by innate immune cells, largely driven by IL1A, IL1B and its consequential effects on IL23A secretion |
|
possible involvement of IL23A in the pathogenesis of polycythemia vera (PV) |
|
IL1A and IL23A signaling seems to be closely regulated through MYD88 in both innate and adaptive immune cells |
|
essential for the differentiation of pathogenic effector T helper 17 (Th17) cells, and in primary and memory Th17 cell responses operates via regulation of proliferation-associated pathways |
|
IL23A and IL17A may play an important role in the pathogenesis of primary biliary cirrhosis (PBC) by promoting inflammation |