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FLASH GENE
Symbol IL21R contributors: mct - updated : 24-03-2016
HGNC name interleukin 21 receptor
HGNC id 6006
Location 16p12.1      Physical location : 27.413.482 - 27.463.362
Synonym symbol(s) NILR, MGC10967, IL-21R
DNA
TYPE functioning gene
STRUCTURE 48.39 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
EPF8 16p12.2 EPF8 pseudogene LOC390686 16 similar to ER degradation-enhancing alpha-mannosidase-like TNT 16p12.2 TNT protein LOC124199 16p12.2 similar to translation Elongation FacTor (eft-4) FLJ13798 16p12.2 hypothetical protein FLJ13798 NSE1 2p25.1 NSE1 IL4R 16p12.11-11.2 interleukin 4 receptor IL21R 16p11 interleukin 21 receptor GTF3C1 16p12.1-p11.2 general transcription factor IIIC, polypeptide 1, alpha 220kDa KIAA0556 16p12.2-p12.1 KIAA0556 protein MGC18079 16p12.1 hypothetical protein MGC18079 XPO6 16p12 exportin 6 LOC390687 16 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) LOC388228 16 similar to SH3-binding kinase LOC388229 16 similar to Group X secretory phospholipase A2 precursor (Phosphatidylcholine 2-acylhydrolase GX) (GX sPLA2) (sPLA2-X) EIF3S8 16p11.2 eukaryotic translation initiation factor 3, subunit 8, 110kDa LOC283890 16p12.1 similar to nuclear pore complex interacting protein LOC388230 16 similar to MGC9515 protein LOC388231 16 LOC388231 SULT1A1 16p12.1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 SULT1A2 16p12-p11.2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 LOC112869 16p12.1 hypothetical protein BC011981 P8 16p11.2 p8 protein (candidate of metastasis 1) IL27  interleukin 27 LOC388232 16 similar to apolipoprotein B48 receptor
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 splicing 4512 59.1 538 - 2000 11081504
  • differing in the 5' UTR as compared to variant 2 and 3
  • encoding the same protein
  • 9 splicing 4865 59.1 538 - 2000 11081504
  • differing in the 5' UTR as compared to variant 1
  • encoding the same protein
  • 10 splicing 5006 - 560 - 2000 11081504
  • differing in the 5' UTR as compared to variant 1
  • encoding the same protein
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly
     thymus   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines lymphoma
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a fibronectin type III domain
  • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • type I cytokine receptor family
  • type 4 subfamily
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I membrane protein
    basic FUNCTION
  • transducing the growth promoting signal of IL21
  • being important for the proliferation and differentiation of T cells,B cells and natural killer (NK) cells
  • involved in the activation of multiple downstream signaling molecules including JAK1, JAK3, STAT1 and STAT3 by ligand binding
  • important amplifier of alternative macrophage activation
  • essential function in the development of pathogen-induced Th2 responses, which may have relevance in therapies for both inflammatory and chronic fibrotic diseases
  • playing a role in regulating immunoglobulin production
  • PTH and IL21R both have potential biologic functions important to bone metabolism
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    IL21/IL21R pathway is a critical component of the memory B cell response
    a component
  • forming a heterodimeric receptor complex with the common gamma-chain
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to JAK1
  • WSB1 associating with the middle part of intracytoplasmic region of IL21R and enhances the maturation of IL21R from N-linked glycosylated form to fully glycosylated mature form
  • is produced predominantly by activated CD4+ T cells and has pleiotropic effects on immunity via IL21R
  • cell & other
    REGULATION
    Other CASP8 cleavage of IL21R is a negative feedback regulator of IL21 signaling
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    IL21 and IL21R expression in lymphocytes and neurons in multiple sclerosis brain
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    blocking IL21R signaling may have a therapeutic potential in inflammatory bowel disease
    ANIMAL & CELL MODELS