Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PRMT8 contributors: mlc/npt - updated : 23-03-2007
HGNC name protein arginine methyltransferase 8
HGNC id 5188
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • unique N-terminal end harboring a myristoylation motif
  • two proline-rich sequences that are predicted to bind SH3 domains, that may function as an autoregulator and may be displaced by interaction with one or more physiological inducers (acting in a regulatory fashion in the autoinhibition of the c-Abl kinase)
    • HOMOLOGY
    interspecies ortholog to murine Prmt8
    intraspecies homolog to HRMT1L2
    homolog to PRMT1 (80 p100)
    Homologene
    FAMILY
  • arginine N methyl-transferase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    text localized to the plasma membrane by N-terminal myristoylation
    basic FUNCTION
  • arginine methyltransferase transferring a methyl group from S adenosylmethionine to the guanidino group nitrogen atoms of specific proteins
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to the hnRNP (heterogeneous nucleoribonucleo proteins)
    • cell & other
    REGULATION
    Other modified by the attachment of a myristate to the glycine residue after the initiator methionine; the myristoylation results in its association with the plasma membrane
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS