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FLASH GENE
Symbol PRMT8 contributors: mlc/npt - updated : 23-03-2007
HGNC name protein arginine methyltransferase 8
HGNC id 5188
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
Reproductivemale systemtestis   
Respiratorylung    
Visualeye    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • unique N-terminal end harboring a myristoylation motif
  • two proline-rich sequences that are predicted to bind SH3 domains, that may function as an autoregulator and may be displaced by interaction with one or more physiological inducers (acting in a regulatory fashion in the autoinhibition of the c-Abl kinase)
    • HOMOLOGY
    interspecies ortholog to murine Prmt8
    intraspecies homolog to HRMT1L2
    homolog to PRMT1 (80 p100)
    Homologene
    FAMILY
  • arginine N methyl-transferase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    text localized to the plasma membrane by N-terminal myristoylation
    basic FUNCTION
  • arginine methyltransferase transferring a methyl group from S adenosylmethionine to the guanidino group nitrogen atoms of specific proteins
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to the hnRNP (heterogeneous nucleoribonucleo proteins)
    • cell & other
    REGULATION
    Other modified by the attachment of a myristate to the glycine residue after the initiator methionine; the myristoylation results in its association with the plasma membrane
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS