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FLASH GENE
Symbol PRKCSH contributors: mct - updated : 10-09-2011
HGNC name protein kinase C substrate 80K-H
HGNC id 9411
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an extremely GLU-rich region
  • two polyadenylation sites
    • HOMOLOGY
    Homologene
    FAMILY PRK family
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text localizes to the endoplasmic reticulum, where it assembles with the glucosidase II alpha subunit
    basic FUNCTION
  • substrate for protein kinase C, playing a role in carbohydrate processing and quality control of newly synthesized glycoproteins in the endoplasmic reticulum
  • probably required for development of bile ducts and does not interact with SEC63
  • PRKCSH and SEC63 function in protein translocation and quality control pathways in the endoplasmic reticulum
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of a cytosolic signal transduction complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly binds activated FGFR1 and forms a ternary complex with growth factor receptor-bound protein 2 (GRB2) and son of sevenless (SOS)
  • TRIM67 regulates RAS signaling via degradation of PRKCSH, leading to neural differentiation including neuritogenesis
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PCLD1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS