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FLASH GENE
Symbol FEZ1 contributors: mct - updated : 30-05-2015
HGNC name fasciculation and elongation protein zeta 1 (zygin I)
HGNC id 3659
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • N terminus, highly acidic, coiled coil domain
  • four coiled-coiled domains
  • a nuclear localization signal
    • HOMOLOGY
    interspecies ortholog to C.elegans Unc76
    intraspecies homolog to FEZ2
    Homologene
    FAMILY
  • zygin family
    • CATEGORY regulatory , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    basic FUNCTION
  • playing a role in axonal outgrowth and fasciculation
  • participating in the establishment of neuronal polarity by controlling the mitochondrial motility along axon
  • participate in the development of the central nervous system during mammalian embryogenesis
  • essential for the establishment of neuronal polarity by controlling the mitochondrial transport in hippocampal neurons
  • neuronal protein that influences axonal development and cell polarization
  • is associated with neuronal development, neuropathologies, and viral infection
  • may play important roles in astrocytes, and mood stabilizers might exert their cytoprotective and mood-stabilizing effects by inducing FEZ1 expression in astrocytes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • SCOC forms a complex with fasciculation and elongation protein zeta 1 (FEZ1)
  • SCOC forms a starvation-sensitive trimeric complex with UVRAG (UV radiation resistance associated gene) and FEZ1
  • dimerizes in its N-terminal region and interacts with other proteins, including the candidate cargoe proteins, through its C-terminus
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PRKCZ
  • PRKCH
  • M17S2 (NBR1)
  • interacts with kinesin superfamily protein 5 (KIF5) and tubulin
  • interacts with other proteins (SCOC), mitochondria, and vesicles
  • DISC1 and its interacting protein FEZ1 positively regulates dendrite growth in young neurons
  • CDC20/APC controls dendrite growth by regulating the degradation of FEZ1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in the brain tissue from schizophrenia
    Susceptibility schizophrenia
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS