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FLASH GENE

Symbol

HSD17B8

contributors: npt/ - updated : 19-05-2006

HGNC name	hydroxysteroid (17-beta) dehydrogenase 8
HGNC id	3554

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	2.19 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 9 - 989 isoform 1 27 261 - Persson (2009)

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Endocrine pancreas         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Ke6

Homologene

FAMILY

short-chain dehydrogenases/reductases (SDR) family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

basic FUNCTION

using estradiol as its preferred substrate

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

hormone

signaling

estrogen biosynthesis

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS