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FLASH GENE
Symbol HSD17B8 contributors: npt/ - updated : 19-05-2006
HGNC name hydroxysteroid (17-beta) dehydrogenase 8
HGNC id 3554
Location 6p21.32      Physical location : 4.404.641 - 33.174.607
Synonym name
  • Ke6 gene, mouse, human homolog of
  • FabG (beta-ketoacyl-[acyl-carrier-protein] reductase, E coli) like
  • estradiol 17 beta-dehydrogenase 8
  • testosterone 17-beta-dehydrogenase 8
  • 17-beta-HSD 8
    • Synonym symbol(s) KE6, RING2, H2-KE6, D6S2245E, FABGL, DHB8, SDR30C1, dJ1033B10.9
    EC.number 1.1.1.62, 1.1.1.63
    DNA
    TYPE functioning gene
    STRUCTURE 2.19 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 989 27 261 - Persson (2009)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrinepancreas    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Ke6
    Homologene
    FAMILY
  • short-chain dehydrogenases/reductases (SDR) family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • using estradiol as its preferred substrate
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism hormone
    signaling
    estrogen biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS