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FLASH GENE
Symbol DPM3 contributors: mct/npt - updated : 25-08-2009
HGNC name dolichyl-phosphate mannosyltransferase polypeptide 3
HGNC id 3007
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • two putative N terminal transmembrane domains, showed no specific functions
  • one hydrophilic C terminal portion
  • near the C terminus, a coiled-coil domain for DPM1 binding (Lefeber 2009) was important for tethering DPM1, the catalytic subunit of the enzyme, to the endoplasmic reticulum membrane and, therefore, was critical for enzyme activity (Ashida 2006)
    • HOMOLOGY
    interspecies homolog to C.elegans y56H1A.2
    Homologene
    FAMILY
  • DPM3 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • stabilizator of DPM1 with enzyme activity
  • required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose (Ashida 2006)
  • plays an important role in four different glycosylation routes in the ER (Lefeber 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    N-glycosylation
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • association to DPM1 to DPM2 by its C and N terminus respectively (DPM1 was rapidly degraded by the proteasome in the absence of DPM3) (Ashida 2006)
    • cell & other
    REGULATION
    Other regulated by phospholipase C gamma
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG1O
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in invasive prostate tumor
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS